FACTORS AFFECTING RIBOFLAVIN PRODUCTION BY ASHBYA GOSSYPII
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چکیده
منابع مشابه
Increased riboflavin production from activated bleaching earth by a mutant strain of Ashbya gossypii.
The production of riboflavin from vegetable oil was increased using a mutant strain of Ashbya gossypii. This mutant was generated by treating the wild-type strain with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Riboflavin production was 10-fold higher in the mutant compared to the wild-type strain. The specific intracellular catalase activity after 3 d of culture was 6-fold higher in the muta...
متن کاملGenome scale metabolic modeling of the riboflavin overproducer Ashbya gossypii.
Ashbya gossypii is a filamentous fungus that naturally overproduces riboflavin, or vitamin B2. Advances in genetic and metabolic engineering of A. gossypii have permitted the switch from industrial chemical synthesis to the current biotechnological production of this vitamin. Additionally, A. gossypii is a model organism with one of the smallest eukaryote genomes being phylogenetically close to...
متن کاملImprovement of Riboflavin Production Using Mineral Support in the Culture of Ashbya gossypii
Riboflavin production in a culture of Ashbya gossypii was enhanced by adding mineral support with adsorbed soybean oil. When the support in an amount of 1 % to the amount of medium was added into the culture at agitation intensity corresponding to impeller rotation rate of 600 rpm, the attained riboflavin concentration was 2.5 g/L at the culture time of 4 days, i.e. 1.6 times higher than that i...
متن کاملAshbya gossypii beyond industrial riboflavin production: A historical perspective and emerging biotechnological applications.
The filamentous fungus Ashbya gossypii has been safely and successfully used for more than two decades in the commercial production of riboflavin (vitamin B2). Its industrial relevance combined with its high genetic similarity with Saccharomyces cerevisiae together promoted the accumulation of fundamental knowledge that has been efficiently converted into a significant molecular and in silico t...
متن کاملMetabolic engineering of riboflavin production in Ashbya gossypii through pathway optimization
BACKGROUND The industrial production of riboflavin mostly relies on the microbial fermentation of flavinogenic microorganisms and Ashbya gossypii is the main industrial producer of the vitamin. Accordingly, bioengineering strategies aimed at increasing riboflavin production in A. gossypii are highly valuable for industry. RESULTS We analyze the contribution of all the RIB genes to the product...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 1949
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.58.6.737-745.1949